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Saccharomyces boulardii is a viable yeast that is genetically different from Baker's yeast, and does not contain milk components. S. boulardii is a true biotic, or living organism, which has been shown to have beneficial effects on intestinal microbalance when administered in adequate amounts. S. boulardii is not part of the naturally occurring gut flora, and is not significantly impacted by antibiotics. Oral administration achieves steady state concentrations in the colon within three days, but does not colonize in the intestinal tract. The organism is typically cleared from the intestinal tract within 2 to 5 days after discontinuation. Each capsule supplies 235 mg of Saccharomyces boulardii, providing a minimum of 4 billion organisms at the time of manufacture.

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There are many different Saccharomyces products commercially available sold as probiotics and S. boulardii is usually available in capsules of either lyophilized or heat-dried preparations [McFarland, 2010]. The choice of a high-quality probiotic product is one of the most important factors that determine efficacy of the probiotic. The quality of these products from different sources may vary and many of the commercially available products may lack regulated quality control programs [Marcobal et al. 2008; Martins et al. 2005; Masco et al. 2005; Weese, 2003]. Even if the label states it contains S. boulardii, a variation in efficacy may occur due to lower than stated dose or inaccurate strain composition [Martins et al. 2009]. Selecting high-quality probiotic products can be difficult without access to specific quality control assays for commercially available probiotic products. Selecting products from companies that sponsor original clinical trials may indicate a higher degree of commitment to high-quality products [McFarland, 2010].

The stability of the probiotic product may significantly affect its potency over time. Lyophilized products are stable at room temperature, have the advantage of portability and maintain high viability counts over prolonged periods [Graff et al. 2008a]. Heat-dried preparations must be refrigerated and may not be stable at room temperature [McFarland, 2010]. A study of S. boulardii products found a lyophilized product outperformed three heat-killed S. boulardii preparations in terms of pharmacokinetics and higher number of viable cells [Schwenzer, 1998].

All of the RCTs using S. boulardii have utilized a single-strain preparation. Although mixtures of probiotics containing S. boulardii are available on the market, no RCTs have been performed showing that these mixtures are superior to the single-strain preparations. Preclinical studies in animal models have found promising results in probiotic mixtures containing S. boulardii [Bisson et al. 2010]. However, possible antagonism between the different probiotics may attenuate the therapeutic responses of the probiotic strains [Kajander et al. 2008].

Several pieces of evidence suggest that S. boulardii represents the most effective probiotic that can prevent or, together with other agents, treat antibiotic-associated diarrhea and recurrent CDI [McFarland, 2006] through many mechanisms (Table 2).

A recent RCT conducted in 100 hospitalized children showed that S. boulardii treatment for 5 days significantly reduces the mean duration of acute diarrhea and frequency of stools, and normalizes stool consistency [Htwe et al. 2008]. One RCT regarding the efficacy of S. boulardii for the prevention of acute diarrhea involved 100 children with acute watery diarrhea and reported a significant difference in the incidence of diarrheal episodes in the group receiving S. boulardii compared with the control group during 2 months follow up [Billoo et al. 2006].

Up to now, almost 100 cases of S. boulardii-associated fungemia have been reported [Vandenplas et al. 2009]. The origin of the fungemia is thought to be either a digestive tract translocation or a contamination of the central venous line by the colonized hands of health workers [Hennequin et al. 2000; Herek et al. 2004]. Indeed, the simple act of opening a packet of S. boulardii can produce air contamination that may pose environmental risk especially for immunocompromised patients [Hennequin et al. 2000]. Once the diagnosis is made, fungemia with S. boulardii can effectively be treated with antimycotic medication, although treatment failure with fluconazole has been reported [Burkhardt et al. 2005].

A rare gastrointestinal allergic reaction was also recently reported after S. boulardii was given to an infant with a prior diagnosis of food protein-induced enterocolitis syndrome [Hwang et al. 2009].

To prevent AAD, S. boulardii should be started early in the course of antibiotic treatment before the change in the gut flora occurs. In clinical trials, S. boulardii is continued for the duration of antibiotic treatment. However, it is unclear whether prolonged use of S. boulardii would be necessary.

Lazo-Vélez MA, Serna-Saldívar SO, Rosales-Medina MF, Tinoco-Alvear M, Briones-García M. Application of Saccharomyces cerevisiae var. boulardii in food processing: a review. J Appl Microbiol. 2018;125(4):943-951. doi:10.1111/jam.14037

Ansari F, Alian Samakkhah S, Bahadori A, et al. Health-promoting properties of Saccharomyces cerevisiae var. boulardii as a probiotic; characteristics, isolation, and applications in dairy products [published online ahead of print, 2021 Jul 13]. Crit Rev Food Sci Nutr. 2021;1-29. doi:10.1080/10408398.2021.1949577

Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793-801. doi:10.1111/apt.13344

Ryan JJ, Hanes DA, Schafer MB, Mikolai J, Zwickey H. Effect of the Probiotic Saccharomyces boulardii on Cholesterol and Lipoprotein Particles in Hypercholesterolemic Adults: A Single-Arm, Open-Label Pilot Study. J Altern Complement Med. 2015;21(5):288-293. doi:10.1089/acm.2014.0063

Our gut microbiomes are unique, so the response to Saccharomyces boulardii varies. If taking Optibac S. Boulardii supplement, each capsule contains 5 billion live cultures. Try 1-2 capsules initially (or a stronger 3-4 capsules together if desired) and increase if necessary up to a maximum of 6 capsules (30 billion live cultures) spread over the day. Within these guidelines, then take as much or as little as you need, on an occasional or ongoing basis.

There are many different probiotics with Saccharomyces boulardii. Some are enhanced with prebiotics (MOS), and others are mixed with probiotic bacteria. Discover the benefits of this probiotic yeast and what health conditions it can help with in this article.

Even though the majority of probiotics are bacterial, some yeasts are good for your health because they are able to combat infections and reduce symptoms, like Saccharomyces boulardii, and S. cerevisiae. That's why they're probiotic.

The benefits of Saccharomyces boulardii mainly apply to your gut where it works to protect against inflammation. It also helps out your immune system, promotes the activities of good bacteria in your gut, and even deters opportunistic microbes that could make you sick.

Infections also hurt the good bacteria in the human gut, but studies show that S. boulardii can help them recover so they can get back work, producing important short-chain fatty acids that keep the gut lining healthy.

The strain of yeast probiotic Saccharomyces boulardii is officially known as Saccharomyces boulardii CNCM I-745. The term lyo does not refer to the yeast, rather it is an abbreviation of lyophilisation (freeze-drying), a technique used to stabilise and protect probiotic supplements.

One review of S. boulardii CNCM I-745 shows that it can help the gut microbiome find stability and prevent diarrhea caused by dysbiosis (an imbalanced gut microbiome). One of its main contributions to gut health is helping good bacteria, which make short-chain fatty acids.

Saccharomyces boulardii MOS side effects are rare. However, you should not take a probiotic containing Saccharomyces boulardii if you are allergic to yeast or using antifungal medication according to

Small studies using a probiotic with Saccharomyces boulardii showed some benefits for these conditions, but researchers warn that stricter clinical trials and larger patient groups are needed to validate these results:

Even though many online articles suggest that Saccharomyces boulardii can make Candida die off, the evidence is very weak. Some studies looking at Saccharomyces boulardii and Candida are 30-40 years old, and the others were conducted in mice and on incubation plates.

Plus, these claims are directly contradicted by a 2011 study where researchers showed that S. boulardii supplements did not prevent Candida albicans infections in mice. Saccharomyces boulardii doesn't treat yeast infections either.

Despite online claims about a Saccharomyces boulardii SIBO cure, there is currently very little evidence to support this. Before taking S. boulardii for SIBO, consult your doctor about testing and a medically-appropriate treatment plan.

Although some websites suggest that Saccharomyces boulardii works for acne, there is no evidence to suggest that this is true. The possible source of confusion is a scientific article from 1918 that suggests S. cerevisiae can help patients with acne.

My Elle is a 10 year old mostly-dachshund rescue. She had chronic diarrhea that could only be arrested with antibiotics. After a year of trial and error and always coming back to antibiotics, I discovered Animalbiome, did the tests, the Gut Restore treatment and finally, the S. boulardii + FOS probiatic/prebiotic powder. The results were fantastic. For the first time, Elle's stools are firm and regular, her skin is shiny and not itchy. She is healthy and happy. For about 6 months now and I understand I can continue to use this product indefinitely. Thank you, Animalbiome!

My little Catahoula-Corgi mix was a sick, itchy mess with horrible soft stools that had globs of mucus. After getting her tested for food allergies and stopping those she cannot eat, she got much better. But her diarrhea just would not stop. These wonderful AnimalBiome folks tested her stool and found out she can't digest carbs, so she gets NO carbs now. That helped a lot more but still the diarrhea wouldn't stop. So these folks recommended this S. boulardii product. I sprinkle just a little on all her meals. Within days, her diarrhea had stopped! Her stools are now healthy looking (and easy to pick up). Her overall health is now good. She seldom scratches at herself. This is a great product. One jar lasts a long time. Thank you AnimalBiome! 041b061a72


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